Events in Dying Cells

Dying cells make a joint

JCB • VOLUME 176 • NUMBER 1 • 2007 4 Dying cel ls make a jo int A leg that doesn’t bend is not much use. To make space for joints in the fruit fl y limb, a thin band of cells are carved out by apoptosis, according to a new study by Cristina Manjón, Ernesto Sánchez-Herrero, and Magali Suzanne (Autonomous University of Madrid, Spain). The team shows that a sharp switch in morphogen signaling dete...

Dying cells say come-hither

Glutamate in unusual places lutamate has a critical physiological function unrelated to its job as a neurotransmitter, according to results from M.M. Reddy and Paul Quinton (University of California, San Diego, CA). The duo find that glutamate activates an epithelial ion channel that is mutated in patients with cystic fibrosis. Cystic fibrosis is caused by mutations in the CFTR anion channel, w...

Genomic DNA Released by Dying Cells

Retinal ganglion cells: dying to survive.

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Clearance of dying cells accelerates malignancy

The breast endures vast changes during reproductive phases of a woman's life (puberty, pregnancy, lactation, post-partum involution, post-menopausal involution). Each phase uniquely shapes cancer susceptibility, formation, and progression. Although pregnancy at a young age decreases lifetime breast cancer risk, the first five years following pregnancy at any age are associated with increased br...